Senior Scientist

We are seeking a highly motivated, lab-based biologist to join our group in Waltham, MA. As a crucial member of a vibrant and collaborative cross-functional team, you will have a crucial part to play in assisting small molecule drug discovery projects. Your primary responsibilities will include validating oncology targets identified through both internal and external research efforts, enabling further drug discovery. You will develop cell-based assays to investigate novel biological mechanisms, implement strategies to identify lead molecules, and elucidate their mechanisms of action. These efforts will contribute directly to the identification of oncology drug candidates and their advancement toward clinical development. This role offers an exciting opportunity to work on a diverse range of projects and collaborate with scientists across multiple fields in a multifaceted and matrix organization.

Major Responsibilities

• Identify and validate oncology targets.
• Use preclinical models including cell lines and organoids, and generate derivative models using genetic approaches.
• Develop, implement, and troubleshoot cell-based phenotypic assays (e.g., proliferation, survival, cell cycle, apoptosis in 2D/3D and clonogenic formats.)
• Develop and implement experiments to evaluate mechanisms of action and identify candidate biomarkers, applying techniques such as western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging assays.
• Analyze, interpret, and communicate research data.
• Maintain clear and accurate experimental records in accordance with standard methodologies for data generation and deposition. This includes generating data for AI application and deployment.

Requirements

• Senior Scientist: Bachelor’s or Master’s degree or equivalent experience with a minimum of 6 years post-graduation research experience, or a PhD or equivalent experience with at least 2 years of post-graduation research experience.
• Demonstrated proficiency in data processing, management and analysis.
• A positive, collaborative demeanor and a desire to learn, as well as the ability to work independently, are highly desired.

Preferred Background

• Knowledge of cancer cell biology and genetics.
• Drug discovery experience in academic, biotech, or pharmaceutical industry settings.
• Familiarity with multiple assay platforms and technologies, along with experience in assay development and automation.
• Experience generating high-throughput data, and ability to analyze such data, including deploying data science and AI tools.

When we put unexpected teams in the same room, we unleash ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are driven by curiosity and courage, exploring what science can achieve. Our dedication to making a difference fuels our passion for innovation, as we fuse data and technology with scientific breakthroughs. We unite diverse knowledge from academia, biotechs, and industry to create swift impacts on disease. Here, lifelong learning thrives as we push boundaries to deliver life-changing medicines. Join us to be part of a team that impacts patients' lives globally.

Ready to make an impact? Apply now and join us on this exciting journey! This position will close on Saturday September 27.